We recognise that this involves 2 differences of two squares. We group it as follows:

r2 s2 + 2st t2 = r2 − (s2 − 2st + t2)

We recognise that s2 − 2st + t2 is a square, and equals (st)2. So we can factor our expression as follows:

r2 s2 + 2st t2 

= r2 − (s2 − 2st + t2)

= r2 − (st)2 [This is also a difference of 2 squares.]

= [r − (st)][r + (st)]

= (rs + t)(r + st)